Clinical study of tranexamic acid combined with intrauterine water sac in the treatment of hemorrhage after placenta previa cesarean section

Abstract

Objective To investigate the effect of tranexamic acid combined with intrauterine water sac on hemorrhage after placenta previa cesarean section. Methods One hundred patients with hemorrhage after placenta previa cesarean section were divided into study group and control group according to the order of admission, with 50 cases in each group. The control group was treated by intrauterine water sac while the study group was treated with tranexamic acid, based on the treatment of control group. The perioperative hemostasis effect and incidence of adverse events after treatment were observed and compared between the two groups. Results After treatment, the hemostasis time of study group [(38.5±4.2) min] was significantly longer than that of control group. The intraoperative bleeding volume was (724.8±33.2) ml, postpartum 2 h bleeding volume was (50.6±6.3) ml, and postpartum 24 h bleeding volume was (150.6±24.3) ml, which were less than those of the control group (P<0.05); The total incidence of adverse events in the study group (6.0%) was significantly lower than that in the control group (24.0%). Conclusions Tranexamic acid combined with intrauterine water sac plays a positive role in the clinical treatment of hemorrhage after placenta previa cesarean section. It not only can effectively reduce the hemostasis time, but also can significantly reduce the intraoperative bleeding volume, postpartum 2 h bleeding volume and postpartum 24 h bleeding volume. Due to the small sample size of this study, a large sample size of study should be carried out in terms of application safety. Key words: Placenta previa; Cesarean section; Postpartum hemorrhage; Tranexamic acid; Intrauterine water sac