Abstract
Ojectvie To investigate therapeutic effect of benazepril on nonproliferative diabetic retinopathy （ NPDR） .Meth-ods Twenty nine patients with early diabetic nephropathy complicated with type 2 diabetes and NPDR were randomly divided into benazepril group （ n =12） and conventional therapy control group （ n =17）.The changes of blood pressure , blood glucose, glycosy-lated hemoglobin , blood creatinine , urinary albumin , best corrected visual acuity （ BCVA ） , and fluorescein fundus angiography （ FFA） were observed before and after 3 and 6 months of treatment .Results After 3 months of treatment by benazepril , all laboratory detection parameters were no significant difference compared with before treatment and conventional therapy control group （ P >0.05）;While after 6 months, compared with before treatment and control group , blood pressure, blood glucose, glycosylated hemoglo-bin, blood creatinine , and urinary albumin were significantly decreased （ P <0.05 ）; According to the results of BCVA and FFA , progression of pathological changes of NPDR were significantly slower in benazepril group compared with control group （ P <0.05 ） . Conclusions Benazepril has some protection effect for NPDR to delay NPDR development and decrease serious complications . Key words: Benzazepines/therapeutic use; Diabetic retinopathy/drug therapy
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