Clinical study of the Guillain-Barré Syndrome

Abstract

Guillain-Barre Syndrome (GBS) is an acute demyelinating neuropathy characterized by progressive generalized paralysis with areflexia. To study the clinical characteristic and outcome of patient with Guillain-Barre syndrome. It was a retrospective analysis conducted in the Department of Neurology, Third Central Hospital of Mongolia from January 2014 to December 2018. We assessed 10 patients history with GBS by Brighton criteria out of 39 patients who diagnosed with the acute polyradiculoneuropathy. The gender ratio was 1: 1, the average age was 57.4 and antecedent illness preceding diarrhea was 60% and 1 case was the upper respiratory tract infection. All had progressive paralysis with areflexia, 90% had sensory loss, 20% had cranial nerve palsies and 1 case had respiratory paralysis with ventilation. The GBS subtype distribution as electro diagnostic studies was as follows: acute motor sensory axonal neuropathy (AMSAN) in 2 (20%), acute inflammatory demyelinating polyradiculoneuropathy (AIDP) in 7 (70%) and equivocal in 1 (10%). Steroids constituted the treatment given in majority of the patients (90%), 2 patients transferred to another hospital to having plasma exchange and intravenous immune globulins (IVIG) was given to 3 cases. Most common antecedent event and presenting feature were diarrhea and progressive paralysis, respectively. Intravenous immune globulins and plasma exchange need to be implemented even further in our practice.