Clinical study of the combined use of TAM and PSA in diagnosis of prostate cancer

Abstract

Objective To investigate the clinical effects of the combined detection of serum tumor associated material（TAM）and serum prostatic specific antigen（PSA）on the differential diagnosis of prostate disease and prostate cancer. Methods The levels of TAM were detected by chemical colori-metry and the levels of PSA were detected by electrochemiluminescence immunoassay. Results The sensitivity of TAM in chronic prostate prostatitis group,acute prostate prostatitis group,BPH group and prostate cancer group was 0. 62% ,1. 94% ,1. 75% and 94. 94% ,respectively. The sensitivity of PSA in the four groups was 40. 12% ,79. 61% ,47. 81% and 96. 20% ,respectively. The sensitivity of the combined use of ATM and PSA was 0. 62% ,0. 97% ,0. 88% and 93. 67% ,respectively. The specifici-ty of TAM was 21. 33% 23. 58% ,25. 27% and 65. 89% ,respectively. The specificity of PSA was 47. 42% ,49. 38% ,53. 62% and 78. 36% ,respectively. The specificity of combined use of ATM and PSA was 20. 17% ,22. 29% ,24. 56% and 98. 26% ,respectively. There were significant differences （P 〈 0. 01）. Conclusions The combined detection of TAM and PSA has good complementary effect on the sensitivity and specificity,and has important clinical value in the differential diagnosis of prostate dis-ease and prostate cancer. Key words: Tumor associated material; Prostatic specific antigen; Prostate cancer; Combined detection