Clinical Study of Rhodanese Enzyme in Renal Failure Patients

Abstract

The research involved clinical study of rhodanese enzyme and its relation with some biochemical parameters in renal failure. The result demonstrated a significant increase in the activity of rhodanese and metallo-endopeptidase and in concentration of urea, and potassium while a significant decrease activity of sulfate oxidase, thiosulfate oxidase and arylesterase and in concentration of albumin and sodium in renal failure patients compared with control. The results also demonstrated a significant decrease in the activity of rhodanese in male compared with female in each of patients and control groups. Correlation coefficients between rhodanese and biochemical parameters of renal failure patients showed that activity of rhodanese has negative correlation with activity of sulfate oxidase, thiosulfate oxidase and concentration of albumin while appositive correlation with activity of metallo –endopeptidase and concentration of urea in renal failure patients. These results provide evidence of a major role for rhodanese enzyme in renal failure, which led to consider it as a marker for renal failure and its relation with biochemical parameters in patients group. .