Abstract
Objective: To explore the clinical efficacy of paliperidone palmitate long-acting injection combined with electroacupuncture in the treatment of methamphetamine addicts. Methods: This study focused on methamphetamine addicts who were admitted to our hospital from January 2020 to December 2020 as the main research object, with a total of 89 cases. The patients were divided into a control group of 45 cases and a study group of 44 cases according to the treatment method. The control group was treated with electroacupuncture, and the study group was treated with paliperidone palmitate long-acting injection on the basis of electroacupuncture in the control group. After 6 months of continuous treatment, the treatment effect of methamphetamine withdrawal symptom score before and after treatment was used; Hamilton Anxiety Scale score and Hamilton Depression Scale were used to compare the anxiety and depression situation of the two groups; the brain wave α and θ wave situation of the two groups were compared. Result: The results showed that there was no significant difference in the scores of Ma withdrawal symptoms, Hamilton Anxiety and Hamilton Depression between the two groups before treatment (p < 0.05); after 3 and 6 months of treatment, the scores of Ma withdrawal symptoms, Hamilton Anxiety and Hamilton Depression in the study group were significantly lower than those in the control group and the difference was statistically significant (p < 0.05); 6 months after the completion of the treatment, the α wave amplitude and Fourier transformed α brain wave (FFTα) in the study group were significantly higher than those in the control group, and the difference was statistically significant (p < 0.05). Conclusion: Paliperidone palmitate long-acting injection combined with electroacupuncture is better than electroacupuncture alone in the treatment of methamphetamine addicts, and can significantly improve anxiety, depression and brain waves, thereby preventing addicts from relapse.
Highlights
Methamphetamine (METH) is a pure white crystal with a similar appearance to ice
This study focused on methamphetamine addicts who were admitted to our hospital from January 2020 to December 2020 as the main research object, with a total of 89 cases
The patients were divided into a control group of 45 cases and a study group of 44 cases according to the treatment method
Summary
Methamphetamine (METH) is a pure white crystal with a similar appearance to ice. It is an amphetamine type central nervous stimulant (Morgan et al, 2010). Paliperidone palmitate long-acting injection has been widely used in the treatment of schizophrenia and other diseases. Paliperidone palmitate long-acting injection can prevent the relapse of METH addicts by regulating the nervous system, but there are not many clinical studies on this aspect. Paliperidone palmitate long-acting injection is a new type of antischizophrenia long-acting injection. It is currently commonly used in the treatment of acute and maintenance schizophrenia. Patients with methamphetamine addiction will experience withdrawal symptoms such as anxiety, irritability and restlessness. Methamphetamine addiction patients often have the same symptoms as patients with schizophrenia, so it could choose the same treatment drug paliperidone palmitate longacting injection
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