Clinical Study of Nano-carbon Combined With 3D Laparoscopic Sentinel Lymph Node Biopsy for Early Cervical Cancer

Abstract

Study Objective To investigate the feasibility and clinical application of early cervical application of nano-carbon tracer imaging of sentinel lymph node (the SLN) under laparoscopic 3D. Design 50 patients diagnosed with early cervical cancer patients, cervical injection nanometers from preoperative Carbon-suspended injection.3D laparoscopic direct recognition of black-stained lymph nodes as SLN and excision, followed by laparoscopic pelvic lymphadenectomy + extensive hysterectomy (+ abdominal para-aortic lymph node sampling). Setting Xinxiang City Central Hospital Gynecologic Oncology, China. Patients or Participants 50 patients diagnosed with early cervical cancer patients were enrolled. Interventions 3D laparoscopic direct recognition of black-stained lymph nodes as SLN and excision, followed by laparoscopic pelvic lymphadenectomy + extensive hysterectomy (+ abdominal para-aortic lymph node sampling). Measurements and Main Results A total of 1476 lymph nodes were removed from 50 patients. SLN was successfully detected. The detection rate of SLN was 100% (50/50). A total of 445 SLNs were detected, accounting for 43.20% (445/1030) of the total number of lymph nodes. SLNB detection sensitivity 100% (50/50), specificity 100.00% (50/50), SLN prediction of pelvic lymph node status and postoperative pathological examination coincidence rate of 100% (50/50), negative predictive value of 100.00% (50/50). Conclusion The metastatic state of SLN in early cervical cancer is consistent with the true metastatic state of pelvic lymph nodes, which has a more accurate pathological representative significance. Laparoscopic detection of SLN in early cervical cancer using nano-carbon tracer is a comparative method. Safe and feasible, SLNB has to replace traditional cervical cancer pelvic lymphadenectomy, narrowing the scope of surgery and reducing trauma.