Clinical study of entecavir combined with dexamethasone for treatment of chronic severe hepatitis B

Abstract

Objective To investigate the effect of entecavir combined with dexamethasone treatment on chronic severe hepatitis. Methods One hundred and twenty-eight patients with chronic severe hepatitis B were randomly divided into treatment group(64 patients) and control group(64 patients), two groups were given the same comprehensive treatment, the treatment group received entecavir and dexamethasone in addition. Results The serum HBV-DNA negative rate was 91.5%(P<0.01) in treatment group, the ALT, TBIL normal rate were 67.2%, 62.5%, total effective rate was 85.9%, mortality was 14.1% in treatment group, which were significantly better than control group(P<0.05). Conclusions Entecavir combined with dexamethasone treatment for chronic severe hepatitis B has good effect. Key words: Chronic severe hepatitis B; Entecavir; Dexamethasone