Clinical study of combinated transcatheter arterial chemoembolization and percutancous acetic acid injection for the treatment of primary carcinoma

Abstract

Objective To observe the effection and survival rate of transcatheter arterial chemoembolization (TACE) combinded with percutaneous acetic acid injection(PAI)in treating primary carcinoma of liver associated with hepatitis B virus infection. Methods 65 patients in mid-advanced primary carcinoma of liver were recruited during January 2006 to June 2008. All the patients were randomly divided into two groups: combination and noncombination therapy. 32 patients were treated by TACE combined with PAI, 33 patients were treated with TACE alone. The effective rates and survival rates were analysed retrospectively. Results 22 patients in combination group were effective, total effective rate was 68.75%, while 14 cases in TACE alone group were effective, the rate was 42.42%, there was a statistical difference between the two groups(x2 = 5.26, P<0.05). The 1, 2,3 year survival rates in combination group were 84.38%,62.50% and 40.62% respectively,while in TACE alone group were 51.52%,24.24% and 9.09%, there were also statistical differences between the two groups (x2 = 6.13,5.44, 4.79, P < 0.05). Conclusions TACE combined with PAI therapy is more effective than TACE alone in treating HCC. Key words: liver neoplasm; Hepatitis B virus; Intervention treatment; Clinical effect