Abstract
Objective: To study the clinical effect of aspirin in the prevention of venous thrombosis in breast cancer patients with postoperative chemotherapy after peripherally inserted central catheter (PICC) insertion. Methods: 240 cases of female breast cancer patients with postoperative chemotherapy after PICC insertion in The First People’s Hospital of Jingzhou from June 2014 to December 2017 were selected and divided into experimental group (n = 120) and control group (n = 120) according to the length of stay. The modified Seldinger technique was used in both groups. The experimental group had oral Aspirin enteric-coated tablet on the day of PICC insertion, 100 mg/day until the PICC catheter was removed, while the control group did not take anticoagulant drugs. The therapeutic effects were evaluated by color Doppler ultrasound, Coagulation analysis, and complete blood count. Results: There were three cases with venous thrombosis in the experimental group, and the incidence rate was 2.5%, while ten cases in the control group developed venous thrombosis, and the incidence rate was 10%. There was a statistically significant difference in the incidence of thrombosis between the two groups (P < 0.05). Conclusion: This study showed that oral Aspirin can effectively reduce the incidence rate of venous thrombosis in breast cancer patients with postoperative chemotherapy after PICC insertion. Therefore, it is worthy of clinical application.
Highlights
The multi-cycle adjuvant chemotherapy has become the most important treatment for breast cancer surgery, and peripherally inserted central catheter (PICC) has been widely used in the chemotherapy of malignant tumors [1]
This study showed that oral Aspirin can effectively reduce the incidence rate of venous thrombosis in breast cancer patients with postoperative chemotherapy after PICC insertion
As 6 - 8 cycles of adjuvant chemotherapy is mostly used in breast cancer patients, long-term indwelling PICC can induce venous thrombosis
Summary
The multi-cycle adjuvant chemotherapy has become the most important treatment for breast cancer surgery, and peripherally inserted central catheter (PICC) has been widely used in the chemotherapy of malignant tumors [1]. As 6 - 8 cycles of adjuvant chemotherapy is mostly used in breast cancer patients, long-term indwelling PICC can induce venous thrombosis. It has been reported in the literature that the incidence of venous thrombosis can be as high as 38% after long-term indwelling PICC and even the severe venous thrombosis can be a life-threatening [2]. It is essential to prevent the formation of thrombosis after PICC insertion At present, it is inconclusive whether the preventive anticoagulant therapy can prevent PICC-related upper extremity venous thrombosis. Findings in another study suggest that the preventive use of anticoagulant drugs can reduce the incidence of venous thrombosis in patients with PICC [4].
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