Abstract
SummaryA review of the published reports of the clinical application of the thyreotropic pituitary hormone is given. Our experience with 24 patients is outlined. In normal patients there is great individual variation in reactiveness to the material, as indicated by the basal metabolic rate. This is also true in castrate women. Some patients with low metabolic rates respond, whereas others do not. Patients with goiters respond with similar individual variation. In one, a diminution of the goiter was observed. Acute temporary exacerbation of hyperthyroidism has been produced in 2 patients; this has been prevented by iodine in others; in one patient with hyperthyroidism refractoriness to the medication seemed present before treatment, and treatment was followed by a fall in metabolic rate.
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