Abstract
ObjectiveThis study aims to analyze the current situation and characteristics of traditional Chinese medicine for treatment of novel coronavirus pneumonia, clarify its clinical advantages and provide a reference for clinical treatment.MethodsClinical randomized controlled trials, clinical control trials and case series research involving the use of Chinese medicine for novel coronavirus pneumonia treatment were selected from PubMed, Chinese Journal Service Platform of CNKI, VIP, and WanFang Data Knowledge Service Platform from the establishment of the library to 11:00 am on April 15, 2020. The published information, research design, intervention measures and research observation index were statistically analyzed.ResultsTwenty studies were included. The research methods were mainly clinical controlled trials. The observation indicators were mostly fever improvement time, cough improvement time, shortness of breath improvement time, chest CT and CRP examination. Maxing Ganshi (Ephedrae Herba, Armeniacae Semen Amarum, Glycyrrhizae Radix Et Rhizoma, and Gypsum Fibrosum) decoction was the core prescription. The most frequently used drugs were Glycyrrhizae Radix Et Rhizoma (Gancao), Ephedrae Herba (Mahuang), Armeniacae Semen Amarum (Kuxingren), Atractylodis Rhizoma (Cangzhu), and Scutellariae Radix (Huangqin). The most frequently used drug combination was Ephedrae Herba (Mahuang)–Armeniacae Semen Amarum (Kuxingren). The most frequently used Chinese patent medicine was Lianhua Qingwen capsule/granule.ConclusionsTraditional Chinese medicine has widely used for novel coronavirus pneumonia in China. It is worthy of global attention. Also, high-quality randomized controlled clinical trials on the effectiveness and safety of traditional Chinese medicine in the treatment of novel coronavirus pneumonia need to carry out.
Highlights
New coronary pneumonia (NCP) outbreaks worldwide, according to the daily information released by the Chinese State and Regional Health Committees’ daily information as of 21:31 on April 16, 2020, China has confirmed a total of 83,798 cases and 3,352 cumulative deaths; among the cumulative confirmed cases of 2,019,857 worldwide, 135,165 died and 1,422,853 remained infected (Dingxiangyuan, 2020)
Exclusion criteria: Studies categorized as review, basic research, regional epidemiological research, experience summary, and syndrome analysis were excluded
20 studies were included in present study (Bin et al, 2020; Cheng and Li, 2020; Cheng et al, 2020; Ding et al, 2020; Duan et al, 2020; Fang et al, 2020; Fu et al, 2020; Gong et al, 2020; Hu et al, 2020; Lv et al, 2020; Qv et al, 2020; Shi et al, 2020; Wang Y. et al, 2020; Wang T. et al, 2020; Xia et al, 2020; Xiao et al, 2020; Yang Q. et al, 2020; Yang Z. et al, 2020; Yao et al, 2020; Zhu et al, 2020)
Summary
New coronary pneumonia (NCP) outbreaks worldwide, according to the daily information released by the Chinese State and Regional Health Committees’ daily information as of 21:31 on April 16, 2020, China has confirmed a total of 83,798 cases and 3,352 cumulative deaths; among the cumulative confirmed cases of 2,019,857 worldwide, 135,165 died and 1,422,853 remained infected (Dingxiangyuan, 2020). The epidemic trend in regions outside of China has greatly erupted, overseas outbreaks have escalated, and more than 20 countries and regions have been infected. How to effectively treat NCP remains a key problem. Zhong Nanshan affirmed the role of Chinese medicine in treatment of NCP; Chinese medicine can effectively suppress inflammatory damages and can be popularized in foreign countries (Tencent News, 2020a). The article aimed to systematically organize clinical research by literature metrology and data mining methods, analyze the current situation of clinical treatment research in Chinese medicine, explore the clinical treatment characteristics of Chinese medicine and provide a reference for global clinical treatment of NCP
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