Abstract
The prognosis was investigated with particular emphasis on the development of DIC (disseminated intravascular coagulation) and MOF (multiple organ failure) in 21 patients with perforation of the colon treated during the period between June 1981 and November 1984. Out of the 21 patients with perforation of the colon, eight (38%) developed DIC, six (29%) developed MOF, and four (19%) resulted in death. All of the patients who died had presented both conditions. Thus, DIC and MOF were the prognostic determinants in these patients. It was considered that sepsis and septic shock were important factors in the development of DIC and MOF and that DIC played an important role in causing and exacerbating MOF. In addition, the presence or absence of preoperative shock and the preoperative leukocyte count found to be useful as indicators for the early prediction of the development of DIC and MOF in perforation of the colon. The more serious the preoperative condition, and the lower the leukocyte count, the higher was the incidence of DIC and MOF and the worse the prognosis.
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