Abstract
This publication provides a study of the efficacy of Tildox AVZ (a combined formulation of doxycycline and tylosin) in non-specific bacterial respiratory and gastrointestinal pathologies in piglets. The study population included 70 piglets with respiratory and gastrointestinal pathologies randomized into 6 groups. The effects of investigational drug used according 3-day or 5-day regimen were assessed using clinical examination, as well as bacteriological, blood count and blood chemistry lab tests. The investigational drug (Tildox AVZ) was safe for target animals and had no adverse effects, showed a similar species specificity and efficacy on the respiratory and gastrointestinal flora in piglets vs. the reference drug (Gentamicin) and allows achieving a beneficial clinical effect in respiratory and gastrointestinal diseases caused by opportunistic microflora. A significant clinical effect is achieved by Day 4 in gastrointestinal pathology and by Days 6-7 in respiratory pathology. Moreover, the control group with gastrointestinal pathology had no changes in the most of the parameters vs. baseline even on Day 7. Tildox AVZ had no adverse effects on blood count and blood chemistry parameters; on the contrary, for a number of parameters, a trend towards normalization was noted. The investigational drug was at least equivalent to the reference one (Gentamicin) and can be used for both respiratory and gastrointestinal disorders caused by the non-specific opportunistic bacterial microflora.
Highlights
IntroductionIn particular pigs, are globally spread and cause great economic losses due to animal mortality and low weight gain [1,2,3,4,5,6]
Bacterial diseases of livestock, in particular pigs, are globally spread and cause great economic losses due to animal mortality and low weight gain [1,2,3,4,5,6]
The following representatives of opportunistic flora were found in nasal washings in piglets with respiratory pathology: S. saprophyticus, Klebsiella sp., Streptococcus sp., S. epidermidis, and Candida sp
Summary
In particular pigs, are globally spread and cause great economic losses due to animal mortality and low weight gain [1,2,3,4,5,6]. In this regard, NVC Agrovetzashchita LLC has developed Tildox AVZ, a drug for use in bacterial respiratory and gastrointestinal diseases of pigs. Tildox AVZ is a light yellow powder; it belongs to combined antibacterial drugs It contains doxycycline and tylosin as active ingredients. The bacteriostatic effect of doxycycline is based on inhibition of the enzymes catalyzing binding of aminoacetyl tRNA to ribosomal
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