Abstract
Six children receiving tridione® showed : 1. A constant syndrome of : a decline in bone marrow megakaryocyte and nucleated red blood cell elements; a low peripheral blood platelet count; and prolonged clot retraction time. 2. An occasional association of: peripheral leukopenia, toxic signs in the red blood cells and lymphocytes, and an abnormal cephalin flocculation response. In one case the bone marrow megakaryocyte response occurred alone and was temporary; in another it was temporary but associated with a persistent decline in marrow nucleated red blood cells; and in a third case both the megakaryocyte and nucleated red blood cell depression were only temporary, despite continuation of the medication. Withdrawal of medication caused a return to normal values, most rapid and marked in the bone marrow. Tests for clot retraction time and platelet counts at regular intervals in addition to complete blood counts seem indicated in all patients receiving tridione®. When available, bone marrow studies, especially of megakaryocytes, would also be of value.
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