Abstract
SUMMARY Results are presented of a comparative clinical trial of thiopentone, buthalitone, hexobarbitone and thiamylal, which extended over five years and was carried out by twenty-three anaesthetists. Thiopentone and thiamylal produced consistently good anaesthesia, but the respiratory and circulatory complications occurring with hexobarbitone and buthalitone were of sufficient frequency and severity as to make their continued use in anaesthesia difficult to justify. Hexobarbitone also caused an unacceptably high incidence of excitatory phenomena, particularly in the absence of opiate premedication. The trial was carried out in several parts, including a double blind study, and the results were pooled with those of three series already published from this department, to produce a total of 15,181 administrations. There was remarkable consistency in the results obtained in different parts of the investigation.
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