Abstract
Cerebral autoregulation (CA) refers to the capability of the brain to maintain relatively constant blood flow within a certain range of arterial blood pressure or cerebral perfusion pressure. In recent years, the application of transcranial Doppler ultrasonography made it possible to detect rapid characteristics of cerebral autoregulation in response to the dynamic changes in blood pressure, which is known as dynamic cerebral autoregulation. Cerebral autoregulation assessment is an interesting tool in understanding cerebrovascular hemodynamics and now has been widely applied in neurological disorders. For cerebrovascular disease, CA is of clinical significance for it may helpful in predicting prognosis and stroke recurrence, improving blood pressure management and delineating optimal therapeutic strategy. For some other diseases that associated with stroke, such as patent foramen ovale (PFO), obstructive sleep apnea-hypopnea syndrome (OSAHS) and insomnia, which have been confirmed sharing an impaired CA, this may suggest an underlying pathogenic mechanism behind stroke. In this lecture, I will briefly introduce our clinical studies of cerebral autoregulation in various neurological diseases.
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