Abstract
Studies were carried out in order to determine the factors influencing myocardial201Thallium uptake in man. A total of 158 patients was examined with regard to both201Thallium uptake and the assessment of left ventricular and coronary function (e.g. quantitative ventriculography, coronary arteriography, coronary blood flow measurements). The results demonstrate: (1) The201Thallium uptake in the normal and hypertrophied human heart is linearly correlated with muscle mass of the left ventricle. (2) The basic correlation between the201Thallium uptake and the left ventricular muscle mass is influenced by alterations in both myocardial blood flow and myocardial oxygen consumption. (3) Inotropic interventions as well as coronary dilatation dipyridamole) may considerably augment the201Thallium uptake in accordance with changes in myocardial oxygen consumption and/or in myocardial flow. (4) In disorders with regional wall motion abnormalities (hypokinesis, akinesis, dyskinesis) a progressive decrease in the quantitative201Thallium uptake of the left ventricle occurs with increase in the degree of wall motion abnormality. (5) The determination of the quantitative201Thallium uptake of the heart enables the evaluation of hypertrophy degree, of regional wall motion abnormalities and of perfusion changes of the myocardium due to primary coronary dilatation and/or metabolically induces flow alteration.
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