Clinical Signs, Causes, and Risk Factors of Pediatric Chronic Kidney Diseases: a Hospital-based Case-control Study

Abstract

Clinical Signs, Causes, and Risk Factors of Pediatric Chronic Kidney Diseases: a Hospital-based Case-control Study Authors Parsa Yousefichaijan1 ; Shobo Rahmati2 ; Abolfazl Mohammadbeigi 3 ; Mahdi Rajbaran4 1Amirkabir Hospital, Department of Pediatric Nephrology, School of Medicine, Arak University of Medical Sciences, Arak, Iran 2Department of Pediatric, School of Medicine, Arak University of Medical Sciences, Arak, Iran. 3Health Policy and Promotion Research Center Assistant Professor, Department of Epidemiology and Biostatistics, Qom University of Medical Sciences, Qom, Iran. 4Department of Public Health, Faculty of Health, Arak University of Medical Sciences, Arak, Iran. Abstract Background This retrospective study aimed to determine the epidemiologic characteristics and risk factors of chronic kidney diseases (CKD) in patients < 18 years old at a single referral center. Materials and Methods In a hospital-based case control study, 66 CKD patients less than 18 years old were compared to 81 control patients (also under 18) without CKD. A patient was defined as a CKD case with renal injury and/or had a glomerular filtration rate (GFR) of Results Fever, chills, and urinary tract infections were the most common clinical signs in the referred patients. Urinary tract infection (39.5%) and growth failure (12.9%) were the most important causes in referred pediatric CKD. After controlling the effect of confounding variables, household income, using packed water for drinking, percentile of body mass index (BMI), and gestational age were the significant predictors of pediatric CKD (P<0.05). Conclusion The most common presentations of the disease were Urinary Tract Infection (UTI) and fever. Reflux nephropathy was the leading cause of CKD in children. Therefore, more attention to children with these signs is essential for early diagnosis. High household income and preterm delivery were the risk factors for CKD in children. Keywords Children; Kidney disease; Pediatric; Renal Insufficiency