Clinical significicance of tumor markers combined detection in screening for tumor high-risk groups

Abstract

Objective To investigate the clinical value of combined detection of tumor markers in screening malignant tumor high-risk population. Methods 3 766 people with malignant tumor high-risk were tested with corresponding tumor markers CA125, CEA, Cyfra21-1, CA19-9, AFP, NSE, CA72 4, SCC, CA153 were rised.These people were inspected with cervico thoracicor, abdominal, and pelvic CT or endoscopy.Moreover, these women were followed up for more than 6 months. Results After follow-up, there were 69 cancer patients were found.Among them, 20 cases (62.5%) were diagnosed in 6 months with rised tumor markers, Five cases(15.9%) were diagosed as cancer in 6 months to 1 year.Four cases (12.5%) were diagosed in 1 to 2 years, and two cases (9.4%) were diagosed in 2 to 3 years. COX analysis showed that the degree of the elevated tumor markers (RR=2.308, 95%CI: 2.517~2.475, P<0.001). The gradually increased tumor markers(RR=7.727, 95%CI: 3.008-19.836, P<0.05), and relevant symptoms (RR=7.879, 95%CI: 2.357-26.384, P<0.05) were the cancer risk factors. Conclusion Combined detection of serum tumor markers is an efficient methed in tumor screening. Key words: Cancer; Early detetion; Tumor markers; Combined detection