Clinical significance on atypical cervical glandular cytology

Abstract

To determine the pathological features and clinical implications of atypical glandular cells of undetermined significance (AGC) in cervical cytological results. All 87 cases of cervical cytological examinations with AGC were identified by a computerized database in our patient population. The authors analyzed the cervical histopathological results by colposcopic biopsy, dilatation and curettage (D&C), cervical loop electrosurgical excision procedure (LEEP)and follow-ups. (1) Thirty-five cases (40.23%) had cervical and endometrial neoplasic findings: ten glandular lesions (11.49%) and squamous lesion was present in 25 patients (28.74%). (2) Among 61 patients with Pap smears subclassified as "AGC-not otherwise specified", there were 18 pathological abnormalities. Sixteen patients with AGC as "favor intraepithelial neoplasia" were of 9 pathological abnormalities. Ten patients with AGC as "adenocarcinoma in situ" or "adenocarcinoma" were of 6 pathological abnormalities. (3) 100% of patients with AGC had both of colposcopic and cytologic follow-ups: 1 case CIN1, 1 case CIN2 and 1 case CIN3. (4) One of 10 patients was younger than 35 years old with CGIN1 and the other 9 patient aged over 35 years old had a greater diversity of glandular lesions. A finding of AGC requires both colposcopy and an aggressive workup because of a high rate of cancer and precancerous lesions. The onset of disease is age-related. Women aged over 35 years old has a greater diversity of glandular lesions and account for most cases of cervical and endometrial adenocarcinoma.