Abstract
A study was conducted to delineate the clinical significance of sperm antibodies in infertile couples. 377 couples who were examined for immunologic infertility between October 1 1967 and August 31 1970 at the University of Michigan Medical Center were sent questionnaires for 2-year follow-up to evaluate subsequent pregnancy rates. 198 couples (52.5%) responded. Of these 159 had negative sperm antibody testing. The pregnancy rate for this group was 51.6%. The pregnancy rate for the 39 couples who had positive sperm antibody tests was 38.5%. 2 of 7 women with circulating sperm-immobilizing antibody became pregnant whereas 8 of 12 women with a sperm-agglutinating antibody were pregnant. Of the 13 husbands who had positive sperm antibody tests 4 of the 8 with only a sperm-agglutinating antibody fathered a child and 5 with either a sperm-immobilizing or both sperm-agglutinating and sperm-immobilizing antibodies did not father any children. These data support those of former investigators who suggested that a sperm-immobilizing antibody is one which impairs fertility.
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