Clinical significance of serum vitamin D levels in children bacterial meningitis

Abstract

Objective To investigate the level of serum vitamin D in the course of bacterial meningitis in children and its clinical relationship with children. Methods Forty-three cases of children with bacterial meningitis admitted to pediatrics department of Lianjiang People’s Hospital from January 2018 to September 2019 were selected as study subjects. The serum vitamin D levels of the children were detected by liquid chromatography-tandem mass spectrometry on day 1, 14 and 28, and the change characteristics of serum vitamin D levels were analyzed. Children were divided into observation group and control group according to the change characteristics of serum vitamin D level, and then the difference of GCS score, pediatric critical illness score (PCIS), cerebrospinal fluid (CSF) biochemistry (WBC, protein, glucose) between the two groups was compared on day 1, 14 and 28. Results Twenty-nine cases showed a continuous decrease in serum vitamin D level, serving as the observation group. Fourteen cases serum vitamin D level showed irregular or continued to increase, serving as the control group. There was a significant difference in vitamin D levels between the observation group and the control group (P 0.05), but it was smaller than that of the control group on day 14 and 28 (P 0.05), but it was higher than the control group on day 14 and 28, with statistical difference (P 0.05), but it was higher than the control group on day 28 (P 0.05), but it was lower than that of the control group on day 14 and 28 (P<0.05). The number of complications and surgical treatment cases in the observation group was lower than that in the control group, and the difference was statistically significant (P<0.05). Conclusion Some children with bacterial meningitis may have an abnormal decrease in serum vitamin D level, which is more likely to cause complications in clinical treatment than normal children with serum vitamin D level, and the probability of requiring surgical treatment is higher, and the recovery of children is slower, which should be paid attention to. Key words: Bacterial meningitis in children; Vitamin D; Rehabilitation