Abstract
Objective To investigate the role and clinical significance of serum levels of visfatin and high mobility groupbox1(HMGB1) in patients with psoriasis vulgaris.Methods Serum levels of visfatin and HMGB1 were measured by double antibody sandwich enzymelinked immunosorbent assay (ELISA) in 78 patients with psoriasis vulgaris.Results The serum levels of visfatin and HMGB1 were significantly higher than those after treatment and in normal controls (P<0.01)，and there were significant difference between the active stage and the rest stage of psoriasis vulgaris (t＝12.47,13.62，P<0.01).The serum levels of visfatin were associated with HMGB1 and PASI scores(r＝0.58,0.67，P<0.01).Conclusions The visfatin and HMGB1 may be very important to the pathogenesis of psoriasis vulgaris.
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