Clinical significance of serum myocardial enzymes and CSF LDH detection in adults with intracranial infection

Abstract

Objective To investigate the changes and clinical significance of serum lactate dehydrogenase (LDH), creatine kinase (CK), glutamate pyruvate transaminase (AST), and cerebrospinal fluid lactate dehydrogenase (CSF LDH) in adult patients with acute central nervous system infection. Methods The levels of myocardial enzymes (AST, LDH, and CK ) in serum of 96 adult patients with acute intracranial infection in 7days and 39 healthy people were measured by Beckman automatic biochemical analyzer and enzyme rate assay, and CSF LDH level in 96 patients were measured simultaneously. Results ⑴The serum myocardial enzymes (LDH, CK, and AST ) of intracranial infection group (47 cases with viral encephalitis, 30 cases with tuberculous meningitis, and 19 cases with purulent encephalitis) were significantly higher than those of normal control group (P 0.05). Conclusions ⑴There is significant change in the levels of serum LDH, CK, AST, and CSF LDH of adult patients with acute intracranial infection, especially in infected patients with cerebral functional disorder, and the change of LDH is the most obvious. ⑵The levels of serum myocardial enzymes and CSF LDH are helpful to the differential diagnosis of intracranial infection in early stage, and judging the severity of the illness. Key words: Tuberculosis, meningeal/ME; Meningitis, viral/ME; Meningitis, bacterial/ME; Lactate dehydrogenases/ME; Creatine kinase/ME; Aspartate aminotransferases/ME