Clinical significance of serum malondialdehyde and total antioxidative capacity in the patients with community-acquired pneumonia

Abstract

Objective To observed serum malondialdehyde(MDA) and total antioxidative capacity (T-AOC) in patients with CAP and to explore their clinical significance.Methods 90 cases of hospitalized CAP (including 54 males and 36 females with a mean age of 54± 20 years) were recruited from the respiratory wards in the affiliated Hospital of Xuzhou Medical College from September 2010 to September 2011 and 30 cases (including 20 males and 10 females with a mean age of 52 ±-11 years) of healthy physical examination in our hospital served as the control.We collected clinical variables of all patients after they were hospitalized within 24 hours and calculated PSI score.The CAP patients were divided into 2 groups:grade Ⅰ-Ⅲ as the low-risk group (n＝46) and grade Ⅳ-Ⅴ as the high-risk group (n＝44)according to PSI score.Serum MDA and total T-AOC were also measured.We adopted t test or x2 test in the comparison between the groups.And performed the logistic regression analysis and found independent risk factors which had important effect on clinical.Results Serum MDA concentration of CAP patients [(6.5±2.4) μmol/L],the high-risk group [(8.1 ± 2.5) μmol/L] and the death group [(9.9 ± 1.6)μmol/L] were significantly higher than those of the control group [(3.6± 0.3) μmol/L],the low-risk group [(4.9 ± 0.7) μmol/L] and the survival group [(6.1 ± 2.2) tmol/L].Serum T-AOC concentration of CAP patients [(12.6± 1.6) U/ml],the high-risk group [(11.5 ± 1.6) U/ml] and the death group [(10.6-1.5) U/ml]were significantly lower than those of the control group [(17.7 ± 2.1)U/ml],the low-risk group [(13.6 ± 0.6) U/ml] and the survival group [(12.8 ± 1.4) U/ml] (P ＜0.05,respectively).There were positive correlation between the serum MDA and PSI score (r =0.745) (P ＜0.05).Serum MDA concentration of the survival patients after the treatment were significantly lower than those before the treatment.Serum T-AOC concentration of the survival patients after the treatment were significantly higher than those before the treatment.We performed the logistic regression analysis and found that serum MDA concentration could reflect the prognosis.Conclusions The serum MDA concentration could reflect the severity and the prognosis of CAP.The dynamic changes of serum MDA concentration and serum T-AOC concentration in patients with CAP could be used for judging the treatment efficacy. Key words: Community-acquired pneumonia; Serum MDA; Serum T-AOC