Clinical significance of serum cardiac tropnin-I in diagnosis and treatment of chronic pulmonary heart disease patients

Abstract

Objective To probe the clinical significance of serum cardiac tropnin-Ⅰ(CTNI)in patients diagnosis and treatment of chronic pulmonary heart disease(CPHD).Methods Blood samples were obtained in 30 patients with CPHD,and 30 patients with chronic obstructive pulmonary disease(COPD)which were both in acute exacerbation and stable stage.Twenty healthy volunteers were included as controls.Results The concentration of CTNI in patients with CPHD during acute exacerbation was(0.02±0.49) μg/L.The concentration of CTNI in patients with CPHD during stable stage was(0.00±0.00) μg/L.The concentration of CTNI in patients with CPHD during acute exacerbation was significantly higher than that in patients with CPHD during stable stage and in the control subjects (P＜0.001).The concentrations of CTNl was(0.00±0.00) μg/L in patients with COPD both acute exacerbation and stable stage.There was significance in patients with COPD between acute exacerbation and stable stage(P＞0.05).The concentration of CTNI in patients with CPHD during acute exacerbation was significantly higher than that in patients with COPD during acute exacerbation and in the control subjects(P＜0.001).Conclusions Myocardieal damage exists in patients with CPHD during acute exacerbation.Higher concentration of CTNI can be a marker for CPHD patients in acute exacerbation.Determination of CTNI provides knowledge about myoeardium damage in time and curative effect. Key words: Cardiac tropnin-Ⅰ; Chronic pulmonary heart disease; Chronic obstruction pulmonarydisease; MyocardieaI damage