Abstract
The aim of this study was to identify the clinical significance associated with ptyalism gravidarum in Japanese singleton pregnancies. Data were collected from 22 patients complicated by ptyalism gravidarum whose symptoms continued until delivery and from 7,743 unaffected controls. The incidence of ptyalism gravidarum in the Japanese pregnant women was about 0.3 %. Using multiple logistic regressions, ptyalism gravidarum was associated with history of hyperemesis gravidarum (p < 0.01), neonatal male sex (p = 0.02) and small for gestational age infants (p = 0.04). Ptyalism gravidarum may be a distinctive condition leading to adverse perinatal outcomes.
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