Clinical significance of preoperative neutrophil / lymphocyte ratio in evaluating the prognosis of patients with acute cholangitis complicated with choledocholithiasis

Abstract

Objective To investigate the clinical significance of preoperative neutrophil/lymphocyte ratio (NLR) in evaluating the prognosis of patients with acute cholangitis complicated with choledocholithiasis. Methods From January 2016 to June 2019, 60 patients with acute cholelithitis complicated with choledocholithiasis were treated in the Department of General Surgery of Wujin people's Hospital affiliated to Jiangsu University, were selected as subjects for retrospective study, including 27 males and 33 females, aged 46-88 years with an average age of (67.93±11.46) years. Preoperative NLR<5.435 patients were treated as low NLR group (31 patients), NLR tientsed as subjects for r(29 patients), white blood cell count, C-reactive protein, glutamic oxaloacetic transaminase and glutamyl transaminase levels were compared between the two groups, and the levels of leukocyte count, C-reactive protein, glutamic oxaloacetic transaminase and glutamyl transaminase in the two groups were analyzed by total hospitalization days, postoperative hospitalization days, total hospitalization expenses, etc. Results The levels of leukocyte count [(6.28±1.66)×109/L vs (10.59±3.55)×109/L, P<0.05 ], C-reactive protein [(57.63±47.68)ug/mL vs (81.38±38.25)ug/mL, P<0.05 ], glutamic oxaloacetic transaminase [(96.17±71.25)U/L vs (281.90±438.30)U/L , P<0.05] and glutamyl transaminase [(297.57±255.97)U/L vs (509.70±462.06)U/L, P<0.05] in low NLR group were significantly lower than those in the high NLR group (P<0.05). The total hospitalization days [(13.34±4.55)days vs (15.49±3.94)days, P<0.05], postoperative hospitalization days [(10.07±2.80)days vs (11.6±3.41)days, P<0.05] and total hospitalization expenses [(26 984.78±4 316.30)CNY vs (30 875.35=±4 305.50) CNY, P<0.05] in the low NLR group were significantly lower than those in the high NLR group (P<0. 05). Conclusion The NLR value of peripheral blood in patients with acute cholangitis with cholelithiasis is positively correlated with the degree of inflammatory infection, suggesting that NLR is consistent with the actual severity of the patient and has a prognosis for surgical treatment. Key words: Prognosis; Neutrophil to lymphocytes ratio (NLR); Acute cholelithiasis with choledocholithiasis; Surgical treatment