Abstract
To analyze clinical significance of preoperative liver stiffness measurement (LSM) by FibroScan in postcurative resection hepatitis B virus (HBV) related hepatocellular carcinoma (HCC). A total of 263 patients underwent preoperative LSM and curative operation for primary HBV-positive HCC were enrolled. The correlation between preoperative LSM and survival was analyzed. All patients were stratified into two groups using the optimal cut-off value (13.2kPa) of LSM using the receiver-operating characteristic. Patients with an LSM≥13.2kPa had poorer overall survival (median, 61.3 vs 48.2months, hazard ratio: 0.15; p=0.009) and recurrence-free survival (median, 60.4 vs 47.0months; hazard ratio: 0.32; p=0.011) than patients with an LSM<13.2kPa and LSM also have been confirmed as independent predictor for survival for HCC. This could potentially guide patient stratification and individualized treatment. Preoperative LSM can be considered as an independent prognostic factor for HBV-positive HCC after curative resection.
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