Clinical significance of peripheral blood leukocytosis in patients with advanced malignant tumors

Abstract

Objective To explore the capability of leukocytosis in predicting the survival time of patients with advanced malignant tumors, in order to provide evidences for clinicians to make the best therapy regimen. Methods The clinical data of 103 dead patients with advanced malignant tumors treated from September 2015 to September 2016 were collected. The relationship between peripheral blood white blood cell count (WBC) and survival time of patients was analyzed retrospectively. The survival analysis was performed by Kaplan-Meier and Log-rank test,and Cox regression was used for multivariate analysis. Results An elevated peripheral blood WBC was found in 61.1% (63/103) dead patients with advanced malignant tumors, and the elevated WBC was negatively correlated with the life span (r=-0.569, P= 0.000). Conclusion Elevated WBC in some advanced malignancy patients predicts they are in the end-stage, which can guide clinicians adjust treatment regimens in time, and they may consider palliative care for those patients. Key words: Neoplasms; Leukocyte count; Prognosis