Clinical significance of palliative gastrectomy on the survival of patients with incurable advanced gastric cancer: a systematic review and meta-analysis

Jingxu Sun,Huimian Xu,Baosen Zhou,Yongxi Song,Peng Gao,Xiaowan Chen,Yingying Xu,Zhenning Wang

doi:10.1186/1471-2407-13-577

Jingxu Sun, Huimian Xu + Show 6 more

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https://doi.org/10.1186/1471-2407-13-577

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Abstract

BackgroundPalliative gastrectomy for patients with advanced gastric cancer remains controversial. The objective of the present meta-analysis was to analyze survival outcomes and establish a consensus on whether palliative gastrectomy is suitable for patients with incurable advanced gastric cancer and which type of patients should be selected to receive palliative gastrectomy.MethodsA literature search was conducted in PubMed, EMBASE and the Cochrane Library. The results for overall survival in the meta-analysis are expressed as hazard ratios (HRs) with 95% confidence intervals (CIs).ResultsOf 1647 articles and abstracts reviewed, 14 studies with 3003 patients were eligible for the final analysis. The meta-analysis revealed that palliative gastrectomy is associated with a significantly improvement in overall survival (HR 0.56; 95%CI 0.39–0.80; p < 0.002) compared that of patients treated without palliative gastrectomy. An improvement in survival was also observed in patients with stage M1 gastric cancer who received palliative gastrectomy (HR 0.62; 95%CI 0.49–0.78; p < 0.0001), especially those with peritoneal dissemination (HR = 0.76, 95%CI 0.63–0.92), liver metastasis (HR = 0.41, 95%CI 0.30–0.55), or distant lymph-node metastasis (HR = 0.36, 95%CI 0.23–0.59). Combined hepatic resection may be beneficial for patients who under palliative gastrectomy (HR 0.30; 95%CI 0.15–0.61; p = 0.0008). The overall survival of patients who underwent palliative gastrectomy combined with chemotherapy was significantly improved (HR 0.63; 95%CI 0.47–0.84; p = 0.002).ConclusionsFrom the results of the meta-analysis, palliative gastrectomy for patients with incurable advanced gastric cancer may be associated with longer survival, especially for patients with stage M1 gastric cancer. Combined hepatic resection for patients with liver metastasis and chemotherapy may be beneficial factors compared to simple palliative gastrectomy.

Highlights

Palliative gastrectomy for patients with advanced gastric cancer remains controversial
The Japanese Gastric Cancer Association (JGCA) guidelines suggest that patients with metastases but without major symptoms may be treated with gastrectomy [11]
The aim of our study was to determine the clinical significance of palliative gastrectomy for patients with incurable advanced gastric cancer (GC) focusing on patient selection and strategy selection

Summary

Introduction

Palliative gastrectomy for patients with advanced gastric cancer remains controversial. The National Comprehensive Cancer Network (NCCN) guidelines suggest that gastric resections should be reserved for the palliation of symptoms (e.g., obstruction or uncontrollable bleeding) in patients with incurable disease [10]. The Japanese Gastric Cancer Association (JGCA) guidelines suggest that patients with metastases but without major symptoms may be treated with gastrectomy [11]. Some other studies reported that survival after palliative gastrectomy was associated with significant morbidity, longer hospital stays, and poor quality of life [18,19], and gastrectomy was recommended only for cases with serious complications, such as tumor bleeding or organ perforation [20,21]

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