Abstract
Agrin has recently been identified as anovel oncogene that is overexpressed in several types ofhuman cancers. However, its role in lung cancer has not yet been investigated. Thepurpose ofthecurrent study was to investigate agrin protein expression in lung cancer and evaluate its clinicopathological and prognostic significance. In this study, Atotal of86 lung adenocarcinoma samples paired with adjacent non-tumour tissue samples and eight lung adenocarcinoma non-paired samples were selected for immunohistochemical staining for agrin. Strong staining ofagrin in nuclei oflung adenocarcinoma tissues was observed, but not in thenuclei ofnormal lung tissues (p<0.001). Consistent with staining in lung adenocarcinoma tissues, thenuclei staining ofagrin was also detected in lung cancer cell lines by immunofluorescence. This is thefirst report demonstrating that agrin is highly expressed in nuclei oflung adenocarcinoma tissues and that it is strongly correlated with lymph node metastasis (p=0.002), clinical stage (p=0.024), and poor differentiation (p=0.022). Agrin-positive nuclear staining oflung adenocarcinoma cells could be used to identify greatly increased risk ofmetastasis in patients after surgery, which might serve as avaluable prognostic marker.
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