Abstract
Diagnostic whole body scan (Dx-WBS) with 131I and serum Tg level are the main parameters to evaluate the effectiveness of thyroid remnant ablation in patients with DTC. Undetectable Tg and positive radioiodine uptake in the thyroid bed (Tg-/Dx-WBS+) may be found in some patients. However, the clinical significance is uncertain. A small amount of thyroidal remnant, a small DTC lesion, increased expression of NIS gene and autoimmune inflammation may all result in Tg-/Dx-WBS+. A wait-and-watch approach without rushing for high-dose radioiodine treatment might be a more reasonable approach for these patients. Key words: Thyroid neoplasms; Surgery, operative; Radiotherapy; Iodine radioisotopes; Thyroglobulin
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