Abstract
Sepsis often leads to a cluster of life-threatening symptoms affecting multiple organ systems. Among the organs most vulnerable to damage in this state is the kidney; those afflicted with severe sepsis frequently encounter acute kidney injury (AKI). The study was to investigate the diagnostic role of miR-625-5p in sepsis and sepsis-induced acute kidney injury (SI-AKI) and predict the possible pathways of miR-625-5p involved in SI-AKI by bioinformatics method. RT-qPCR was used to detect the level of miR-625-5p, and the diagnostic value of miR-625-5p was analyzedusing ROC curve. The proliferation and the concentration of inflammatory factors of HK-2 cells induced by LPS were detected by CCK-8 and ELISA. The pathway of miR-625-5p involved in SI-AKI was analyzed by bioinformatics method. The miR-625-5p expression was downregulated in sepsis as well as SI-AKI and has predictive value for sepsis as well as SI-AKI. In addition, miR-625-5p promoted LPS-induced cell proliferation and inhibited the levels of inflammatory cytokines. miR-625-5p may be a diagnostic biomarker for SI-AKI.
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