Abstract
AimsCurrently, there is no reliable method to effectively predict and diagnose early-onset preeclampsia (EOPE). microRNAs (miRs) are promising biomarkers for EOPE. This study investigated the role of miR-320a in EOPE. MethodsExpressions of miR-320a and insulin-like growth factor-1 receptor (IGF-1R) in serum of EOPE patients and normal pregnant women were detected. The clinical diagnostic efficacy of miR-320a and IGF-1R for EOPE was analyzed using receiver operating characteristic curve. The correlation between miR-320a expression and EOPE clinical indicators [mean arterial pressure (MAP), 24-h urinary protein excretion, serum creatinine (SCR), uric acid (UA), albumin (ALB) and platelet count] was analyzed. The correlation and binding relationship between miR-320a and IGF-1R was predicted and verified. ResultsmiR-320a was upregulated, and IGF-1R was downregulated in EOPE patients with their differential expressions more obvious in severe EOPE than mild EOPE. miR-320a and IGF-1R possessed potent clinical diagnostic efficacy for EOPE. miR-320a expression showed a positive correlation with MAP, 24-h urinary protein excretion, UA and SCR levels, and a negative correlation with ALB level and platelet count in EOPE patients. Moreover, miR-320a targeted IGF-1R. ConclusionWe demonstrated that miR-320a was aberrantly elevated in EOPE and showed powerful clinical diagnostic efficacy for EOPE, which may be achieved by directly targeting IGF-1R. This study provided great reference values for EOPE early diagnosis and novel targets for EOPE treatment.
Highlights
Preeclampsia (PE), a multisystem pregnancy syndrome, causes serious impacts on 2–8% pregnant women globally [1]
Results miR-320a was upregulated, and insulin-like growth factor-1 receptor (IGF-1R) was downregulated in early-onset preeclampsia (EOPE) patients with their differential expressions more obvious in severe EOPE than mild EOPE. miR-320a and IGF-1R possessed potent clinical diagnostic efficacy for EOPE. miR-320a expression showed a positive correlation with mean arterial pressure (MAP), 24-h urinary protein excretion, uric acid (UA) and serum creatinine (SCR) levels, and a negative correlation with ALB level and platelet count in EOPE patients
We demonstrated that miR-320a was aberrantly elevated in EOPE and showed powerful clinical diagnostic efficacy for EOPE, which may be achieved by directly targeting IGF-1R
Summary
There is no reliable method to effectively predict and diagnose early-onset preeclampsia (EOPE). microRNAs (miRs) are powerful and promising biomarkers in multiple diseases, including EOPE. There is no reliable method to effectively predict and diagnose early-onset preeclampsia (EOPE). MicroRNAs (miRs) are powerful and promising biomarkers in multiple diseases, including EOPE. The present study investigated the role of miR-320a in EOPE
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