Abstract
To investigate the clinical significance of MDR1 andMDRP gene expression in patients with non-small cell lung cancer (NSCLC) . Using reverse transcription polymerase chain reaction (RT-PCR) technique , the expression of MDR1 and MDRP gene was determined in cancer and paracancerous tissues from 33 NSCLC patients. Positive expression of MDR1 gene was 69.7% and 36.4% in lung cancer tissues and paracancerous tissues respectively , and a highly significant difference was observed between the two groups ( P < 0.01) . The expression levels of MDR1 mRNA were much higher than those in paracancerous tissues. The positivity rate of MDRP gene expression in cancer tissues was 63.6% , which was higher than 30.3% in paracancerous tissue. The gene expression levels in cancer tissues were also significantly higher than those in paracancerous tissues. The expression levels of MDR1 and MDRP in cancer tissues of the patients receiving pre-operative chemotherapy were remarkably higher than those of the patients not receiving chemotherapy ( P < 0.05) . NSCLC had primary and acquired multidrug resistance. It was of important significance to detect MDR1 and MDRP gene expression in directing chemotherapy of lung carcinoma and in predicting prognosis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
