Abstract
Objective To investigate the association of situation of HLA antibody with biliary cast syndrorne(BCS)in patients after liver transplantation and explore the role of HLA antibody in predicting BCS caused by immunization.Methods A total of 416 serum samples were collected at 8 time phases before and after liver transplantation from 52 patients.The 52 patients were divided into the BCS group(n=32)and NBCS group(n=20).The HLA-Ⅰ and HLA-Ⅱ antibodies in the serum samples were detected with ELISA.Meanwhile,ALT,AST,ALP,GGT,TB and DB were determined,Results The positive rate of HLA was significantly higher in the BCS group than in NBCS group (P<0.05).The recovery time of biliary complications were negatively correlated to the appearance time of HLA-Ⅱ antibody.Conclusion HLA-Ⅱ antibody can be dynamically monitored to help predict the biliary complications in liver transplantation recipients. Key words: Liver transplantation; HLA antibody; Biliary cast syndrome(BCS)
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