Clinical Significance of Gamma-Glutamyltranspeptidase Combined with Carbohydrate-Deficient Transferrin for the Assessment of Excessive Alcohol Consumption in Patients with Alcoholic Cirrhosis.

Hirotetsu Takagi,Kyoji Moriya ,Yukihisa Fujinaga,Daisuke Kaya,Masanori Furukawa,Masahide Enomoto,Hitoshi Yoshiji,Yuki Fujimoto,Takahiro Kubo,Yosuke Tsuji ,Yasuhiko Sawada,Takemi Akahane,Shinya Sato,Akira Mitoro,Junya Suzuki,Hideto Kawaratani,Kosuke Kaji,Norihisa Nishimura,Takashi Inoue,Satoshi Iwai,Naotaka Shimozato,Koh Kitagawa,Tadashi Namisaki,Hiroyuki Ogawa,Akihiko Shibamoto,Koji Ishida,Fumimasa Tomooka,Takahiro Ozutsumi,Kōji Murata ,Soichi Takeda,Hiroaki Takaya

doi:10.3390/medicines8070039

Abstract

Background: This study aimed to compare the diagnostic performance of carbohydrate-deficient transferrin (CDT) and gamma-glutamyltranspeptidase (γ-GTP) to assess the single and combined benefits of these biological markers for the detection of chronic excessive alcohol consumption in patients with alcoholic cirrhosis. Methods: Biological markers were determined in blood samples from patients with alcoholic cirrhosis (drinking group, n = 35; nondrinking group, n = 81). The prediction accuracy of %CDT alone, γ-GTP alone, and their combination for the detection of excessive alcohol consumption was determined in patients with alcoholic cirrhosis. Results: Serum total bilirubin, alanine aminotransferase, aspartate aminotransferase, γ-GTP, and alkaline phosphatase levels and %CDT were significantly higher and serum albumin levels were significantly lower in the drinking group than in the nondrinking group. The combination of %CDT and γ-GTP compared with %CDT or γ-GTP alone showed a higher prediction accuracy. The combination of %CDT and γ-GTP exhibited a higher specificity than γ-GTP alone. However, in terms of sensitivity, no significant difference was found between single or combined markers. Conclusions: The combination of %CDT and γ-GTP is considered a useful biomarker of chronic excessive alcohol consumption in patients with alcoholic cirrhosis.

Highlights

Liver cirrhosis (LC) represents the irreversible, advanced stage of various chronic liver diseases and has become one of the leading causes of morbidity and mortality worldwide, including in Asia [1]
Alcohol-related liver disease (ARLD) is characterized by liver injury induced by alcohol abuse and eventually develops in several stages, beginning with hepatic steatosis, and, in some individuals, developing gradually into alcoholic hepatitis, followed by alcoholic liver fibrosis, with up to 20% of cases progressing to alcoholic cirrhosis [6]
A combination of %carbohydratedeficient transferrin (CDT) and γ-GTP was found to be a useful marker of excessive alcohol consumption in patients with alcoholic cirrhosis

Summary

Introduction

Liver cirrhosis (LC) represents the irreversible, advanced stage of various chronic liver diseases and has become one of the leading causes of morbidity and mortality worldwide, including in Asia [1]. This study aimed to compare the diagnostic performance of carbohydratedeficient transferrin (CDT) and gamma-glutamyltranspeptidase (γ-GTP) to assess the single and combined benefits of these biological markers for the detection of chronic excessive alcohol consumption in patients with alcoholic cirrhosis. Methods: Biological markers were determined in blood samples from patients with alcoholic cirrhosis (drinking group, n = 35; nondrinking group, n = 81). The prediction accuracy of %CDT alone, γ-GTP alone, and their combination for the detection of excessive alcohol consumption was determined in patients with alcoholic cirrhosis. Conclusions: The combination of %CDT and γ-GTP is considered a useful biomarker of chronic excessive alcohol consumption in patients with alcoholic cirrhosis

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