Clinical significance of expression of Survivin and caspase-3 on ovarian epithelial tumor

Abstract

Objective To investigate the expression of apoptosis regulatory factor Survivin and caspase-3 in epithelial ovarian tumor and its clinical significance.Methods The expression of proteins Survivin and caspase-3 in 40 cases of epithelial ovarian tumor,10 cases of borderline epithelial ovarian tumora and 10 cases of benign ethelial tumor were detected by immunohistochemistry; then the clinical and pathological features were analyzed.Results There was a negative correlation of Survivin and caspase-3 expression in epithelial ovarian tumor; the expression rate of Survivin in epithelial ovarian cancer was 72.5％ (29/40),and it was higher than that in epithelial ovarian tumor and borderline epithelial ovarian tumor(P ＜ 0.05).The expression rate of caspase-3 in epithelial ovarian cancer was 0.5％(2/40),and it was more lower than that in epithelial ovarian tumor and borderline epithelial ovarian tumor(P ＜0.01).Conclusions The expression of caspase-3 is inhibited by Survivin,which results in the ovarian cancer cells multiplication,apoptosis obstruction and tumor generation; The expression of Survivin gene happens in the early stage of ovarian cancer malignant transformation; The expression of Survivin is closely correlated with tumor cell differentiation and proliferation,and its high expression can be the identification marker of unfavourable prognosis; The expression level of caspase-3 in ovarian cancer is quite low,which makes it a new index to identify the benign and malignant ovarian tumor; The qualitative and quantitative analysis of Survivin,caspase-3 and PCNA may become the index of curative effect of drugs. Key words: Survivin; Caspase-3; Ovarian cancer