Abstract
Objective To study the diagnostic values of co-detections of traditional serum tumor marker(Cyfra21-1) and serum proteomic patterns by surface-enhanced laser desorption and ionization time-flight mass spectrometry(SELDI-TOF-MS) technology in patients with lung squamous carcinoma.Methods Serum samples of 59 lung squamous carcinoma patients and 60 healthy controls were detected by electrochemiluminescence to analyze the levels of Cyfra21-1,meantime SELDI-TOF-MS and CM10-chips were employed to detect the differential expressions of proteins in serum.Combined with clinical pathological materials,the diagnostic values of two methods combination were evaluated.Results The sensitivity and specificity of Cyfra21-1 detection were 77.966% and 96.667%,while SELDI-TOF-MS technology were 83.051% and 65.385%.Combined detections of two methods were 94.915% and 95.000% respectively.Conclution The sensitivity of co-detection was higher than that of single detection.The specificity of co-detection was higher than that of SELDI-TOF-MS technology.
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