Clinical Significance of C-reactive Protein Level After Laparoscopic Gastrectomy: From a Viewpoint of Intra-Abdominal Complications

Abstract

In this retrospective study, we investigated whether postoperative intra-abdominal infectious complications (IIC) after laparoscopic gastrectomy (LG) is predictable in an early postoperative period using C-reactive protein (CRP). Intra-abdominal infectious complication after gastrectomy is caused mainly by anastomotic leakage or pancreatic injury associated with peripancreatic lymph node (LN) dissection, which may sometimes result in serious outcomes. C-reactive protein is widely used to evaluate the inflammatory status. However, the relationship between the CRP level and postoperative IIC following LG remains unclear. White blood cell count (WBC), CRP counts, and clinical data were available for 229 consecutive patients undergoing LG with lymphadenectomy. We compared CRP and WBC between patients with (Group A) and without (Group B) IIC to check whether these could be used to predict IIC in an early postoperative period. Using the receiver-operating characteristic (ROC) curve, the diagnostic accuracy was evaluated. On postoperative day 1 (POD1), increased CRP levels were associated with IIC (Group A: 9.6 mg/dL, Group B: 6.0 mg/dL; P = 0.000048), while WBC did not differ significantly. On POD3, the difference in CRP between both groups increased (A: 20.2 mg/dL, B: 10.7 mg/dL; P = 1.6 × 10−8). The optimal cutoff value was 14.9 mg/dL on POD3 (sensitivity: 0.79, specificity: 0.78), and the area under the ROC curve was 0.86. Measurements of CRP on POD1 and 3 are helpful for detecting possible IIC after LG, compared with WBC. It is necessary to pay attention to CRP levels for earlier detection of IIC.