Abstract
IntroductionThis study aims to investigate the association between the presence and frequency of cortical lesions (CLs), and the clinical and psychological features of multiple sclerosis (MS).MethodsA total of 19 patients with MS were examined using double inversion recovery (DIR) sequences with 3T magnetic resonance imaging (MRI) and classified into two groups: CL and non‐CL. In‐house software was used to quantitatively determine the atrophy of each brain region. Activities of daily living (ADL) were estimated using the Kurtzke Expanded Disability Status Scale (EDSS). Cognitive function was assessed using the following tests: Mini‐Mental State Examination (MMSE), Trail Making Test (TMT), and Paced Auditory Serial Addition Task (PASAT). Z‐scores were used to assess significant differences in the neuropsychological test outcomes between the groups.ResultsSix of 19 patients had subcortical and deep WM lesions (non‐CL group; diagnosed with relapsing–remitting MS). Thirteen of 19 patients had both subcortical and cortical lesions (CL group; 9—relapsing–remitting MS; 4—primary/secondary progressive MS). There were no significant differences in age, education, and disease duration, but EDSS scores were significantly higher in the CL group compared to the non‐CL group. There were no significant differences in gray and white matter volume between the CL and the non‐CL groups, but the white matter lesion volume was significantly higher in the CL group compared to the non‐CL group. Neuropsychological tests showed significant performance worsening in the CL group as compared to the standard values for healthy individuals in their age group, especially in the TMT data.ConclusionsProgressive MS, which was associated with decreased physical functioning, ADL, and cognitive impairment, was found in patients in the CL group.
Highlights
This study aims to investigate the association between the presence and frequency of cortical lesions (CLs), and the clinical and psychological features of multiple sclerosis (MS)
There were no significant differences in the gray matter (GM) and white matter (WM) volumes between the CL and the non-CL groups
With regard to cognitive function, there were no significant differences in the Mini-Mental State Examination (MMSE) score, Raven’s Colored Progressive Matrices (RCPM) score, RCPM time, Rivermead Behavioral Memory Test (RBMT) standardized profile score (SPS), RBMT SS, Trail Making Test (TMT)-A, category word fluency (WF) task performance, letter WF task performance, visuospatial construction copying performance, visuospatial construction drawing performance and 1-s Paced Auditory Serial Addition Task (PASAT), and 2-s PASAT between the CL and non-CL groups (Table 2)
Summary
This study aims to investigate the association between the presence and frequency of cortical lesions (CLs), and the clinical and psychological features of multiple sclerosis (MS). Results: Six of 19 patients had subcortical and deep WM lesions (non-CL group; diagnosed with relapsing–remitting MS). Thirteen of 19 patients had both subcortical and cortical lesions (CL group; 9—relapsing–remitting MS; 4—primary/secondary progressive MS). There were no significant differences in age, education, and disease duration, but EDSS scores were significantly higher in the CL group compared to the non-CL group. B-cell follicle-like structures are detected in the inflamed meninges of some patients with MS, which correlate with increased subpial demyelination and cortical atrophy (Magliozzi et al, 2007). CLs occur when there is microglial activation in the lymph follicle structures (Howell et al, 2011) These ectopic lymph follicle-like structures contain abundant B cells and plasma cells and cause demyelination in the cerebral cortex adjacent to the lymph follicle (Magliozzi et al, 2007)
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