Abstract
The stomach is the main digestive organ in humans. Patients with gastric cancer often develop digestive problems, which result in poor nutrition. Nutritional status is closely related to postoperative complications and quality of life (QoL) in patients with gastric cancer. The controlling nutritional status (CONUT) score is a novel tool to evaluate the nutritional status of patients. However, the relationship of the CONUT score with postoperative complications, QoL, and psychological status in patients with gastric cancer has not been investigated. The present follow-up study was conducted in 106 patients who underwent radical gastrectomy in our hospital between 2014 and 2019. The CONUT score, postoperative complications, psychological status, postoperative QoL scores, and overall survival (OS) of patients with gastric cancer were collected, and the relationship between them was analyzed. A significant correlation was observed between the CONUT score and postoperative complications of gastric cancer (P < 0.001), especially anastomotic leakage (P = 0.037). The multivariate regression analysis exhibited that the CONUT score (P = 0.002) is an independent risk factor for postoperative complications. The CONUT score was correlated with the state anxiety questionnaire (S-AI) for evaluating psychological status (P = 0.032). However, further regression analysis exhibited that the CONUT score was not an independent risk factor for psychological status. Additionally, the CONUT score was associated with postoperative QoL. The multivariate regression analysis exhibited that the CONUT score was an independent risk factor for the global QoL (P = 0.048). Moreover, the efficiency of CONUT score, prognostic nutrition index, and serum albumin in evaluating complications, psychological status, and QoL was compared, and CONUT score was found to outperform the other measures (Area Under Curve, AUC = 0.7368). Furthermore, patients with high CONUT scores exhibited shorter OS than patients with low CONUT scores (P = 0.005). Additionally, the postoperative complications (HR 0.43, 95% CI 0.21–0.92, P = 0.028), pathological stage (HR 2.26, 95% CI 1.26–4.06, P = 0.006), and global QoL (HR 15.24, 95% CI 3.22–72.06, P = 0.001) were associated with OS. The CONUT score can be used to assess the nutritional status of patients undergoing gastric cancer surgery and is associated with the incidence of postoperative complications and QoL.
Highlights
Gastric cancer has become a common malignant disease, with high incidence and mortality in modern China because of the accelerated pace of life and dietary changes[1]
The present retrospective study attempted to clarify whether the controlling nutritional status (CONUT) score could accurately assess the preoperative nutritional status of patients with gastric cancer and its association with postoperative complications, quality of life (QoL), and psychological status
According to the CONUT score items, data on the lymphocyte count, ALB, and total cholesterol levels of patients with gastric cancer were collected within 2 weeks before the surgical procedure, whereas the data on carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) levels were collected within 1 month before the operation
Summary
Gastric cancer has become a common malignant disease, with high incidence and mortality in modern China because of the accelerated pace of life and dietary changes[1]. The nutritional status of patients with gastric cancer must be accurately assessed Nutrition evaluation systems such as NRS2002 and patient-generated subjective global assessment (PG-SGA) are widely used in the clinic for patients with tumors. These assessment methods have significant drawbacks due to the tedious, complex, time-consuming, and subjective processes. It is limited by the memory and knowledge level of patients; several patients cannot recall and provide the nutritional status accurately. The present retrospective study attempted to clarify whether the CONUT score could accurately assess the preoperative nutritional status of patients with gastric cancer and its association with postoperative complications, QoL, and psychological status
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
