Clinical significance of Caveolin-1 and RhoE expression in the carcinogenesis of primary liver carcinoma

Abstract

Objective To investigate the expression of Caveolin-1 and RhoE in primary liver carcinoma (PLC),and their relation to the clinicopathological features and the prognostic value.Methods Immunohistochemical method was used to assess the expression of Caveolin-1 and RhoE in 20 normal liver tissues,32 cirrhosis tissues and 68 PLC tissues.Results The expression rate of Caveolin-1 in normal liver tissues,cirrhosis tissues and PLC tissues was 85.00％ (17/20),56.25％ (18/32) and 27.94％ (19/68) with significant difference (P ＜ 0.05).The expression levels of Caveolin-1 were related to histology grade and blood vessel invasion of PLC (P ＜ 0.05).The expression rate of RhoE in normal liver tissues,cirrhosis tissues and PLC tissues was 95.00％ (19/20),71.88％ (23/32) and 50.00％ (34/68) with significant difference (P ＜ 0.05).There was a close relation between the expression of RhoE and histology grade,blood vessel invasion and TNM stage (P ＜ 0.05).Conclusion The expression of Caveolin-1 and RhoE may play an important role in the carcinogenesis of liver carcinoma. Key words: Primary liver carcinoma; Caveolin-1 ; RhoE