Clinical significance of cardiac biomarkers increasing and their interrelations in surgery with cardio-pulmonary bypass

Abstract

Levelfor cardiac troponin I (TrI) and MB-fraction of creatine kinase (CKMB) increases in cardiomyocyte necrosis, and B-type natriuretic peptide (of BNP) increasing reflects ventricular overload. to study the dynamics of BNP, TRI and CKMV in myocardial revascularisation with cardio-pulmonary bypass and to evaluate the clinical significance of these biomarkers elevated levels and establishing the relationship between BNP and markers of myocardial damage in the perioperative period Materials and methods. The study included 52 patients aged 62.5 (54.75; 70) years. Biomarkers concentrations was determined by immunofluorescence. The initial value of BNP were 57.9 (38.675;88.5) pg/ml, and then increased (p<0,01): at the end of the operation up to 91.75 (59.6;132.75) pg/ml, at 1st day following surgery - up to 260 (157;407) pg/ml, and at 2nd day - up to 184 (115.25;274.5) pg/ml. TrI and CKMV increased (p<0,01) up to 0.95 (0.4175;1.4525) ng/ml and up to 13.1 (5.575;15.525) U/L at the end of surgery, and up to 1,355 (0.76;3.8) ng/ml and 10.5 (5;18.325) U/L at thr Istpostoperative day. Preoperative BNP level and TrI level at the end of surgery were the predictors (p<O. 05) of inotropes dosages at the end of surgery and in the postoperative period, and of the duration of the intensive care unit stay. Postoperative BNP values did not affect the studied clinical parameters, but had expressed connection with increased postoperative cardiac enzyme levels. Maximum postoperative BNP values correlate with maximum values of TrI (r = 0, 77; p <0,01) and CKMV (r = 0,81; p <0,01). The identifed strong correlations give reason to consider the postoperative release of BNP as an adaptive reaction in response to a "minor myocardial damage" as a result of surgical trauma and myocardial, ischemia during aorta cross-clamping.