Abstract
IntroductionAutoantibodies to Ro52 recently identified as TRIM21 are among the most common autoantibodies in systemic autoimmune rheumatic diseases, but their clinical association remains poorly understood. We undertook this study to determine the clinical and serologic associations of anti-Ro52/TRIM21 antibodies in patients with systemic sclerosis (SSc).MethodsDetailed clinical data and sera from 963 patients with SSc enrolled in a multicenter cohort study were collected and entered into a central database. Antibodies to Ro52/TRIM21 and other autoantibodies were detected with an addressable laser-bead immunoassay and different enzyme-linked immunosorbent assay (ELISA) systems. Associations between anti-Ro52/TRIM21 antibodies and clinical and other serologic manifestations of SSc were investigated.ResultsAnti-Ro52/TRIM21 antibodies were present in 20% of SSc patients and overlapped with other main SSc-related antibodies, including anti-centromere (by immunofluorescence and centromere protein (CENP)-A and CENP-B ELISA), anti-topoisomerase I, anti-RNA polymerase III, and anti-Pm/Scl antibodies. Anti-Ro52/TRIM21 antibodies were strongly associated with interstitial lung disease (odds ratio (OR), 1.53; 95% confidence interval (CI), 1.11 to 2.12; P = 0.0091) and overlap syndrome (OR, 2.06; 95% CI, 1.01 to 4.19; P = 0.0059).ConclusionsAnti-Ro52/TRIM21 antibodies were the second most common autoantibodies in this SSc cohort. In SSc, anti-Ro52/TRIM21 antibodies may be a marker of interstitial lung disease and overlap syndrome.
Highlights
Autoantibodies to Ro52 recently identified as TRIM21 are among the most common autoantibodies in systemic autoimmune rheumatic diseases, but their clinical association remains poorly understood
Another, which often coexists with the former SS-A/ Ro60 antibodies, is directed against a 52-kDa (Ro52) protein that is not normally part of the small cytoplasmic ribonucleoprotein (scRNP) complex but is an E3 ubiquity ligase and a member of the tripartite motif (TRIM) family of proteins known as TRIM21 [10]; the preferred terminology of Ro52/TRIM21 is used in this report
This represents the second most common autoantibody in this cohort with anti-centromere, anti-RNA polymerase III, and anti-topoisomerase I antibodies present in approximately 35%, 19%, and 16% of the patients, respectively (Table 1)
Summary
Autoantibodies to Ro52 recently identified as TRIM21 are among the most common autoantibodies in systemic autoimmune rheumatic diseases, but their clinical association remains poorly understood. We undertook this study to determine the clinical and serologic associations of anti-Ro52/TRIM21 antibodies in patients with systemic sclerosis (SSc). Systemic sclerosis (SSc; scleroderma) is a disorder characterized by fibrosis of the skin and visceral organs. The pathogenesis of this disease is complex and remains incompletely understood. Two main types of SS-A/Ro antibodies have been described in SSc. One is directed at a 60-kDa protein known as SS-A/Ro60, which is part of a small cytoplasmic ribonucleoprotein (scRNP) multiprotein complex. Little is known of their clinical associations, and controversy still exists about whether they have an independent association with autoimmune diseases [11]
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