Clinical significance of AFP detection for secondary liver cancer and primary liver cancer

Abstract

Objective To explore the clinical diagnosis meaning and value of AFP on secondary liver cancer and primary liver cancer.Method Selected 87 patients diagnosed with liver cancer from July 2009to December 2010 in our hospital.Tested their serum AFP and recorded their serum AFP＞ 20 μ g/L,and ＞ 400μ g/L.When serum AEP ＞ 400 μ g/L,it is positive.Result 46 primary liver cancer patients' serum AFP＞20 μ g/L.39 patients were positive(serum AFP ＞400 μ g/L) ; positive rate was 81.25％.And among the secondary liver cancer patients,19 cases' serum alphafetoprotein ＞ 20 μ g/L; 10 cases' Serum AFP was positive; the positive rate was 25.64％.Primary liver cancer' serum alphafetoprotein positive rate was obviously higher than secondary liver cancer'.There was significant difference on positive diagnosis rate between the two groups(P＜0.05).Gonclusion Using serum AFP to diagnose primary liver cancer has a higher accuracy rate than to diagnose secondary liver cancer,but its sensitivity and specificity are insufficient ideal; assisting with other laboratory diagnosis can improve liver cancer diagnosis rate. Key words: Primary liver cancer (PHC); Secondary liver cancer(MHC); AFP clinical significance