Clinical significance and relationship between gastric bare area involved in gastric carcinoma and expression of CD34, VEGF and VEGF-C

Abstract

AIM: To detect the expression of CD34, vascular endothelial growth factor (VEGF) and vascular endothelial growth factor C (VEGF-C) in gastric carcinoma, and to investigate the clinical significance and relationship between the gastric bare area (GBA) involved in gastric carcinoma and expression of CD34, VEGF and VEGF-C. METHODS: Seventy-two cases of gastric carcinoma were divided into GBA involved and non- involved groups. Expression of CD34, VEGF and VEGF-C was detected by immunohistochemistry. RESULTS: In gastric carcinoma, there was no significant difference in the expression of VEGF (27/32 vs 28/40), CD34 (61.67±21.33 vs 60.79±22.04) or VEGF-C (23/32 vs 26/40) in GBA involved and non-involved groups. In proximal gastric carcinoma, there was no significant difference in the expression of VEGF (23/30 vs 6/9), CD34 (62.48±20.12 vs 61.79±23.68) and VEGF-C (20/30 vs 6/9) in GBA involved and non-involved groups. CONCLUSION: There was no relationship between the GBA involved in gastric carcinoma and expression of CD34, VEGF and VEGF-C. The anatomical structure of the GBA may result in poor prognosis of gastric carcinoma.