Clinical significance and expression of long chain noncoding taurine up-regulated gene 1 in human gastric carcinoma

Abstract

Objective To investigate the clinical significance of long chain noncoding taurine up-regulated gene 1 (TUG1) RNA in human gastric carcinoma. Methods Human gastric cancer and matched normal gastric tissue were collected, and TUG1 were detected by fluorescence quantitative real-time fluorescent quantitative polymerase chain reaction (FQ-PCR) assay. The relation of between TUG1 expression and patient’s sex, age, tumor location, tumor diameter, Lauren type, histological differentiation, depth of tumor invasion, lymph node transfer shift, distant metastasis, TNM staging and signet ring cell and vascular tumor thrombus and other clinicopathological factors was analyzed, respectively. Results The results showed that TUG1 expression was not significantly correlated with the patient gender, age, tumor location, tumor diameter, Lauren type, histological differentiation, signet ring cells had no significant correlation, but was significantly correlated with tumor invasion depth (P<0.01), lymph node metastasis (P<0.05), distant metastasis (P<0.05), TNM staging (P<0.05) and tumor thrombus (P<0.02). Further results was found that TUG1 expression level is one of the important independent risk factors influencing the prognosis of patients with gastric cancer. Conclusion TUG1 might be one of the important targets in the diagnosis and treatment of gastric cancer. Key words: Gastric carcinoma; Long chain noncoding RNA; Taurine up-regulated gene 1